A12 NOTCH PATHWAY IS INVOLVED IN MURINE ARTICULAR CHONDROCYTE DEDIFFERENTIATION

Extracellular Matrix Delays Articular Chondrocyte Dedifferentiation and Enhances Redifferentiation

Introduction Articular cartilage is a highly specialized tissue that is vulnerable to injury and disease and has a limited capacity for self-regeneration. The autologous chondrocyte transplantation technique has not been successful because of rapid dedifferentiation of chondrocytes in monolayer culture, producing fibroblast-specific markers (mainly collagen I) rather than a cartilage-specific m...

Articular Chondrocyte Maturation Is Induced by Shifting Signaling Dominance from Thetgf-beta to the Bmp Pathway

Introduction. Maintenance of the articular surface depends on the function of articular chondrocytes (ACs) which produce matrix and are constrained from undergoing terminal maturation. Under some circumstances, such as in osteoarthritis, these constraints are lost and ACs enter the maturational program that occurs during endochondral ossification. The aim of this study was to identify these unk...

2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes.

2-deoxy-D-glucose (2DG) is known as a synthetic inhibitor of glucose. 2DG regulates various cellular responses including proliferation, apoptosis and differentiation by regulation of glucose metabolism in cancer cells. However, the effects of 2DG in normal cells, including chondrocytes, are not clear yet. We examined the effects of 2DG on dedifferentiation with a focus on the beta-catenin pathw...

Dystroglycan is involved in skin morphogenesis downstream of the Notch signaling pathway

Dystroglycan (Dg) is a transmembrane protein involved both in the assembly and maintenance of basement membrane structures essential for tissue morphogenesis, and the transmission of signals across the plasma membrane. We used a morpholino knockdown approach to investigate the function of Dg during Xenopus laevis skin morphogenesis. The loss of Dg disrupts epidermal differentiation by affecting...

Chondrocyte multiplication in osteoarthritic articular cartilage.